Non-IgG Antibody

IgE antibody, also known as immunoglobulin E, is the least abundant isotype that only presents in mammals. IgE antibody is similar to IgG antibody in structure, which is both Y-shaped. Generally, IgE antibodies are composed of two identical light chains and heavy chains (ε chain), where each light chain contains 1 variable domain and 1 constant domain while each heavy chain contains 1 variable domain and 4 constant domains. IgE is a heavily glycosylated antibody having a total of 6 N-linked glycosylation sites, of which glycans make up more than 10% of its molecular mass.